Sterilizing-Grade Filter(PES 0.45+0.2 μm)
Product Introduction
Alioth Alipore® CHC double-layer polyethersulfone (PES) filters are suitable for a variety of sterile filtration of process fluids with both cartridge and disposable capsule format available. The filter has passed strict sterilization performance validation. It features a built-in pre-filtration layer to achieve high flow rate and capacity, and thereby optimize your process efficiency and cost effectiveness.
Key Features and Benefits
- Highly asymmetric Double-layer PES membrane
- High flow rates and high capacity
- Validated reliable bacterial retention
- Wide chemical compatibility (pH 1-14)
- 100% integrity tested
Typical Applications
- Buffers
- Final Fill
- Cell Culture Media
- Process Intermediates
- Water for pharmaceutical process
Typical Flow Characteristics
Water Flow Rate and Pressure Drop -Alipore® CHC 0.45+0.2μm Cartridge Filters
Product Characteristics
| Cartridge Filter (5 inch) |
Cartridge Filter (10 inch) |
Cartridge Filter (20 inch) |
Cartridge Filter (30 inch) |
Capsule Filter (5 inch) |
Capsule Filter (10 inch) |
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| Dimensions Diameter Body Diameter Maximum Width Maximum Length |
69 mm |
69 mm |
69 mm |
69 mm |
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| Filtration Area | 0.3 m2 | 0.6 m2 | 1.2 m2 | 1.8 m2 | 0.3 m2 | 0.6 m2 |
| Pore Size | 0.45+0.2 μm | |||||
| Structural Materials | Filter membrane: Hydrophilic polyethersulfone (PES) Supporting Layer: Polypropylene O-rings of cartridges: Silicone Liner / cartridge body: Polypropylene End caps: Polypropylene / Polycarbonate |
Filter membrane: Hydrophilic polyethersulfone (PES) Supporting Layer: Polypropylene O-rings of capsules vent: Silicone Liner / cartridge body: Polypropylene Housing : Polypropylene |
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| Bacterial Retention | ＞107 cfu /cm2 B. diminuta ( ATCC® 19146TM ) | |||||
| Maximum Differential Pressure |
Forward: 5.0 bar（72.5 psi）@ 25°C / 3.0 bar（43.5 psi）@ 80°C Reverse: 2.0 bar（29.0 psi）@25℃ |
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| Bubble Point | ≥3520 mbar（51 psi）(wetted with H2O, 20℃, compressed air） | |||||
| Diffusion | Through a water wet membrane at 2760 mbar (40 psi) （20℃, compressed air ） | |||||
| ≤12.5 mL/min | ≤25 mL/min | ≤50 mL/min | ≤75 mL/min | ≤12.5 mL/min | ≤25 mL/min | |
| Sterilization | Steam in place: 136℃, 30 min, 30 cycles Autoclave: 131℃, 30 min, 30 cycles |
Autoclave(A&G): 131℃, 30min, 5 cycles Gamma-compatible (G): 50 kGy *Cannot be steam sterilized in-line, Pre-sterilized capsule filters must not be re-sterilized |
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| Biological Safety | All the construction components of this filter comply with the requirements for biological safety of Class VI plastics in current USP <88> | |||||
| Indirect Food Additive | The primary construction components of this filter comply with the requirements for food contact materials as stipulated in EU 1935 / 2004 / EC and FDA 21 CFR 177-182 | |||||
| Cleanliness | Cleanliness meets the requirements for nonfiber releasing filter as specified in FDA 21 CFR211.72 and 210.3 (b) (5) (6), and the level of insoluble particles in rinsing liquid meets the requirements of USP <788> | |||||
| Endotoxin | The endotoxin level of cartridge rinsing liquid is <0.25 EU/mL as indicated by gel method, which complies with the requirements of USP <85> | |||||
| TOC / Conductivity | Filtrate of this filter , TOC＜0.5 mg/L, Conductivity＜1.3 μS/cm | |||||
| Integrity | Filters are 100% integrity tested | |||||
| Manufacturing Environment |
Manufactured in conformance with cGMP | |||||
Ordering Information
Cartridge Filters
Capsule Filters
For further information, please contact us and Alioth technical team will provide a comprehensive service for your filtration process.
