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depth filters also retain bacteria?

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Bacterial Challenge Test


high precision depth filter can be usedreduction of microorganisms, thereby reducing the microbial load prior to sterilization filtration. The purpose of the bacterial retention test is to demonstrate that the filtration process can consistently remove high levels of standard bacteria or potentially contaminating microorganisms.


When testing using depth filtration, the main purpose is usuallyconfirms its effectiveness in reducing microbes.sterilization grade filteris to challenge at least 107CFU/cm2defects of short-wave single-cell bacteria, and can stabilize the output of sterile feed, and.depth filterusually throughcalculation of microbial decline indexfor characterization, such as upstream total CFU/downstream total CFU, or log-down value LRV. The same challenge microorganisms should generally be employed in validation studies and characterization studies.

Feed liquid composition(e. g. formulation ingredients or additives),Feed liquid characteristics(such as pH, viscosity or ionic strength),process conditions(temperature, time or batch size) andMicrobial speciescould beaffects the bacteria retention capacity of the filter. Therefore, manufacturers usually determine the typical degradation performance under actual operating conditions. The LRV value of the test microorganism is determined under the specified test conditions. These data can aid in depth filter selection for reducing microbial load.


protection sterilization filter


In many applications, depth filters are used in conjunction with sterilizing filters to form sequential filtration. Although in many cases depth filtration can effectively reduce the microbial load,cannot use it as a sterilization filter. High-precision depth filters can provide downstream sterilization filtration processesprotective role.


depth filters also reduce particulate contaminants, therebyincreases the load capacity of downstream sterilization filters. Typically in membrane filter applications, turbidity and clogging are not directly related. Tiny particles, which have very little effect on turbidity, may penetrate the deep filter and cause blockage of membrane filtration. Therefore inProcess Development Research Phaseshouldto study and screen the combination of depth filtration and terminal filtration. Special attention should be paid to the load of the deep filter to avoid particle penetration.


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