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Sterilizing-Grade Cartridge Filter(PES 0.45+0.2 μm)

Product Introduction

Alioth Alipore® CHC double-layer polyethersulfone (PES) filters are suitable for a variety of sterile filtration of process fluids with both cartridge and disposable capsule format available. The filter has passed strict sterilization performance validation. It features a built-in pre-filtration layer to achieve high flow rate and capacity, and thereby optimize your process efficiency and cost effectiveness.


Key Features and Benefits

  • Highly asymmetric Double-layer PES membrane
  • High flux and increased capacity
  • Validated reliable bacterial retention
  • Wide chemical compatibility (pH 1-14)
  • 100% integrity tested


Typical Applications

  • Buffers
  • Final Fill
  • Cell Culture Media
  • Process Intermediates
  • Water for pharmaceutical process


Typical Flow Characteristics

Water Flow Rate and Pressure Drop -Alipore® CHC 0.45+0.2μm Cartridge Filters


Water Flow Rate and Pressure Drop-Alioth Alipore® CHC 0.45+0.2μm Alicap L-type Capsule Filter



*T1, T3, B5, B7 represent different interface types, see order information for details.


Product Specifications —Cartridge Filter

  Cartridge Filter
(5 inch)
Cartridge Filter
(10 inch)
Cartridge Filter
(20 inch)
Cartridge Filter
(30 inch)
Maximum Length


69 mm
150 mm


69 mm
320 mm


69 mm
560 mm


69 mm
800 mm

Filtration Area 0.3 m2 0.6 m2 1.2 m2 1.8 m2
Pore Size 0.45+0.2 μm
Materials of
Filter membrane: Hydrophilic polyethersulfone (PES)
Supporting Layer: Polypropylene
O-rings of cartridges: Silicone
Liner / cartridge body: Polypropylene
End caps: Polypropylene / Polycarbonate
Bacterial Retention >107 cfu /cm2 B. diminuta ( ATCC® 19146TM )
Maximum Differential
Forward: 5.0 bar(72.5 psi)@ 25°C / 3.0 bar(43.5 psi)@ 80°C
Reverse: 2.0 bar(29.0 psi)@25℃
Bubble Point ≥3520 mbar(51 psi)(wetted with H2O, 20℃, compressed air)
Diffusion Through a water wet membrane at 2760 mbar (40 psi) (20℃, compressed air )
≤12.5 mL/min ≤25 mL/min ≤50 mL/min ≤75 mL/min
Sterilization Steam in place: 136℃, 30 min, 30 cycles
Autoclave: 131℃, 30 min, 30 cycles
Biological Safety All the construction components of this filter comply with the requirements for biological safety of Class VI plastics in current USP <88>
Indirect Food Additive The primary construction components of this filter comply with the requirements for food contact materials as stipulated in EU 1935 / 2004 / EC and FDA 21 CFR 177-182
Cleanliness Cleanliness meets the requirements for nonfiber releasing filter as specified in FDA 21 CFR211.72 and 210.3 (b) (5) (6), and the level of insoluble particles in rinsing liquid meets the requirements of USP <788>
Endotoxin The endotoxin level of cartridge rinsing liquid is <0.25 EU/mL as indicated by gel method, which complies with the requirements of USP <85>
TOC / Conductivity Filtrate of this filter , TOC<0.5 mg/L, Conductivity<1.3 μS/cm
Integrity Filters are 100% integrity tested
Manufactured in conformance with cGMP

Ordering Information

Cartridge Filters


For further information, please contact us and Alioth technical team will provide a comprehensive service for your filtration process.