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Single-layer Cartridge Filter (PES 0.45μm)

Product Introduction

Alioth Alipore® CHF PES prefilters can provide effective bioburden control and particle contaminants removal with good chemical compatibility and low level extractable. Alipore® CHF filters aresuitable for bioburden control and prefiltration application of various kind of fluid,provide effective protection to downstream sterilizing-grade filter and other processsystem in different steps of bioprocess. Meet the common needs of the pharmaceutical industry for liquid pre-filtration.


Key Features and Benefits

  • High flow rate, high capacity
  • Valicated bioburden reduction
  • Stable performance, Withstand multiple
  • cycles of sterilization
  • Broad chemical compatibility


Typical Applications

  • Pre-fltration for buffers
  • Cell culture media
  • Pre-filtration for column protection
  • Pre-filtration before terminal sterilization, etc
  • Alioth Filter Series
  • Differential


Typical Flow Characteristics

Product Specifications

  5 inch 10 inch 20 inch 30 inch


Maximum Length


69 mm
150 mm


69 mm
320 mm


69 mm
560 mm


69 mm
800 mm

Filtration Area 0.32 m2 0.65 m2 1.3 m2 1.95 m2
Materials of Construction

Filter membrane: Hydrophilic polyethersulfone (PES)       

Supporting Layer: Polypropylene (PP)
O-rings of capsules vent: Silicone

Liner/Cartridge body: Polypropylene (PP)
End caps: Polypropylene/ Polycarbonate (PP/PC)

Pore Size 0.45 μm
Maximum Differential
Forward: 5.0 bar ( 72.5 psi ) @ 25℃ / 3.0 bar ( 43.5 psi ) @ 80℃ / Reverse: 2.0 bar ( 29.0 psi ) @ 25℃
Sterilization Parameters 135℃, 30 minutes, 10 cycles of high-pressure sterilization or 10 cycles of sterilization in place
Biological Safety All the construction components of this cartridge comply with the requirements for biological safety of Class Vl plastics in current USP < 88 >
Indirect Food Additive The primary construction components of this cartridge comply with the reguirements for food contact materials as stipulated in EU 1935 / 2004 / EC and FDA 21 CFR 177-182
Cleanliness Cleanliness meets the requirements for nonfiber releasing filter as specified in FDA 21 CFR 211.72 and 210.3 (b) (5) (6), and the level of insoluble particles in rinsing liquid meets the requirements of USP < 788 >
Endotoxin The endotoxin level of cartridge rinsing liquid is < 0.25 EU/mL as indicated by gel method, which complies with the requirements of USP < 85 >
TOC / Conductivity TOC < 0.5 mg/L, Conductivity < 1.3 μS/cm
Manufacturing Environment Manufactured in conformance with cGMP



Ordering Information


For further information, please contact us and Alioth technical team will provide a comprehensive service for your filtration process.